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ISRS/AAO Member Communication [6]

【时间:2011-10-12 16:59】 【作者:admin】【查看次数:3280】
ISRS - Academy Express
A weekly news brief from the American Academy of Ophthalmology (AAO) and the International Society of Refractive Surgery of the American Academy of Ophthalmology (ISRS/AAO)

Editor-in-Chief: David W. Parke II, MD

Chief Medical Editor: Andrew G. Iwach, MD

Managing Editor: Susanne Medeiros
AAO Advisory Panel:
Terry L. Forrest, MD, Jean E. Ramsey, MD
Franco M. Recchia, MD, James C. Tsai, MD
Eliza Hoskins, MD, Sunita Radhakrishnan, MD

ISRS/AAO Advisory Panel:
Matteo Piovella, MD, John A. Vukich, MD

 Contact Us e-mail aeisrsaao@aao.org    
Vol. III, No. 37
September 18, 2009
Twitter: Follow AAO

CONTENTS

New Journal Studies

Academy News


NEW JOURNAL STUDIES

Laser therapy appears safer than corticosteroids for BRVO and equally effective
This phase III clinical trial conducted at 84 sites compared the efficacy and safety of 1-mg and 4-mg doses of preservative-free intravitreal triamcinolone with standard laser grid photocoagulation in 411 patients with branch retinal vein occlusion (BRVO). Patients could receive treatment every four months for up to three years. At one year, visual gain was similar between the two groups. However, patients receiving either dosage of corticosteroid were more likely to develop a cataract or have increased IOP requiring medication than patients in the laser group. Between one and two years after treatment began, patients who received the 4-mg dosage were also more likely to undergo cataract surgery. Archives of Ophthalmology, September 2009

Endothelial cell loss after Ahmed valve implantation increases progressively over time
Researchers prospectively evaluated changes in the corneal endothelium of 41 patients (41 eyes) implanted with the Ahmed glaucoma valve. The average percentage decrease in all fields of the corneal endothelium were 5.8 percent, 11.5 percent, 15.3 percent, 16.6 percent, and 18.6 percent at one, six, 12, 18 and 24 months after surgery, with the greatest loss occurring in the supratemporal area (22.6 percent). These changes were significant compared with baseline densities and with controls (P < .05). The authors conclude that alternative treatments should be considered for patients with significantly low cell density before surgery. American Journal of Ophthalmology, September 2009

Eye drop demonstrates ability to stop progression of corneal neovascularization
This double-blind, placebo-controlled study evaluated the efficacy of GS-101 eye drops in 40 patients who were non-responsive to conventional therapy for progressive corneal neovascularization. GS-101 eye drops are an antisense oligonucleotide designed to inhibit corneal neovascularization by only targeting actively growing new vessels. Patients were divided into three groups and were treated for three months at different doses, while one group received placebo. Eye drops dosed at 86 μg/day stopped progression of corneal neovascularization and reduced regression of newly outgrowing blood vessels. Safety data indicates treatment was well-tolerated. Ophthalmology, September 2009

Study finds increased prevalence of conjunctival bacteria among diabetics
This large retrospective study assessed the conjunctival bacterial pattern in patients with diabetes undergoing cataract surgery and compared it to non-diabetics also undergoing cataract surgery. Diabetics had a significantly higher prevalence of Staphylococcus aureus, Enterococci, certain Streptococci and Klebsiella sp. than nondiabetics. The authors conclude that this pattern is a predominant cause of many diabetic infections. They also found that an abnormally high blood creatinine level (greater than 105.2 µmol/l) is an indicator of increased conjunctival colonization in diabetics and non-diabetics. Eye, published electronically Aug. 28, 2009

Arcuate keratotomy with a femtosecond laser can correct high astigmatism after keratoplasty
This preliminary study included nine patients (nine eyes) with a  mean spherical equivalent refraction of ­2.50±3.60 D after penetrating keratoplasty. The three-month follow-up showed good predictability. Mean refractive astigmatism decreased by 6.00 D, mean keratometric value decreased by 4.60 D. Mean spherical equivalent refraction did not change significantly, and there was a statistically insignificant increase in BSCVA. Journal of Refractive Surgery, August 2009

Animal study: injectable lipid prodrugs show promise as long-lasting, slow release agents against CNV, PVR
Researchers synthesized three crystalline lipid prodrugs and injected them at escalating doses in rabbit eyes, with fellow eyes serving as controls. Efficacy was then studied in a rat choroidal neovascularization (CNV) model or rabbit proliferative vitreoretinopathy (PVR) model. The results suggested that two of the prodrugs might be effective long-lasting, slow-release antiproliferative compounds for inhibiting the development of CNV and PVR. The results also confirmed that crystalline intraocular drug delivery could be used with these and other small molecule compounds and possibly biologically active peptides. Investigative Ophthalmology & Visual Science, September 2009

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ACADEMY NEWS

Experts to discuss reducing preventable blindness at the Joint Meeting in San Francisco
The topic for this year’s International Forum is Debates and Updates: Pediatric Cataract, Volunteering, and VISION 2020 – The Next Decade. Community and international efforts, such as VISION 2020, have significantly reduced preventable blindness worldwide, yet more work remains. A panel of analysts puts the problem into perspective.

Don’t miss your opportunity to network in San Francisco
Many medical alumni and related ophthalmic groups plan events to coincide with the Academy’s meeting. View online the event list for this year’s Joint Meeting in San Francisco and contact the organization for more event information.

More than 700 images available for download from the Image Collection
The Image Collection on the O.N.E. Network recently expanded by more than 100 additional clinical images. There are now more than 700 high-quality images, with more added all the time. These images are perfect for illustrating the information you share with colleagues, residents or patients. Get three months of unlimited downloads with your paid subscription, $49 member / $63 nonmember. To browse new images first, select “By Date” from the Sort drop-down menu.

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The Academy provides the items appearing in the Academy Express as a service. The articles and studies come from news reports and peer-reviewed journals, and are not the product, opinion or position of the Academy unless explicitly stated to be so. The Academy does not endorse products, companies or organizations. The Academy disclaims all liability. If you would like to update your e-mail address or be removed from the mailing list, please send a request to ISRS/AAO.

©2009 American Academy of Ophthalmology. All rights reserved.


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